eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-02-16 2 2 357 362 858 article Ranjit Patil 1 Uplabdhi Raghuwanshi 2 Medical Biochemistry Department, Dr. Ulhas Patil Medical College, Jalgaon, (India). Maharashtra University of Health Sciences, Nashik, B.J. Medical College, Pune (India). A reduction of/disruption in blood flow to the brain is the primary cause of a stroke. Low LDL-c and high HDL-c – is the key to control damage for ischemic stroke. The present study aims at – (1) The effect of derangement of lipid profile in stroke (CVA) patients; and (2) The effect of stroke on derangement of lipid profile; both on 1st and 7th day. The study included 25 patients of stroke whose 12 – 14 hr fasting samples were obtained, within 24 hours of admission, i.e. on 1st and 7th day. The measured lipid profile levels (TC, HDL-c, TG, LDL-c, & VLDL-c were compared to the normal range (130 to 250 mgs/dL, 30 to 70 mgs/dL, 70 to 170 mgs/dL, upto 110 mgs/dL, & < 40 mgs/dL, respectively). It was found that measured mean value of serum TC was 190.24 mgs/dL, HDL-c = 38.68 mgs/dL, TG = 147.32 mgs/dL, LDL-c = 122.48 mgs/dL, & VLDL-c = 29.48 mgs/dLwith corresponding normal values on the 1st day, which on the 7th day showed decreased levels for 158.16 mgs/dL, 35.68 mgs/dL, 128.88 mgs/dL, 97.36 mgs/dL, & 25.64 mgs/dL, correspondingly. In conclusion since all lipid parameters showed a considerable decrease on 7th day, as the stroke severity decreased, it could be proportionally linked with the severity of stroke. Thus stroke causes a significant derangement in lipid parameters. Individuals with low HDL-c should be considered a group at high risk of stroke, whereas direct relationship has been observed with levels of TC, LDL-c, TG, & VLDL-c (comparing 1st day with control). https://biomedpharmajournal.org/vol2no2/derangement-of-lipid-profile-in-stroke-patients/ Total Cholesterol High-density lipoprotein cholesterol Triglyceride Low-density