eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-02-16 2 2 333 338 962 article V. Ravichandiran 1 V. Suba 2 S. K. Umadevi 2 G. Jayavasavi 1 J. Kausalya 1 T. Saraswathy 3 Vels college of Pharmacy, Pallavaram, Chennai (India). Department of Pharmacology, Vels college of Pharmacy,Pallavaram,Chennai. Madras Medical College, Chennai - 3 (India). In the body under physiological conditions, many vital functions are regulated by transient release of bioactive substances at a specific time and site. Thus, to mimic the function of living systems and in view of emerging chronotherapeutic approaches, pulsatile delivery, which is meant to release a drug following programmed lag phase, has attracted increasing interest in recent years. In pursuit of pulsatile release, various design strategies have been proposed, broadly categorized into single-unit and multiple-unit systems. However, in recent pharmaceutical applications involving pulsatile delivery, multiparticulate dosage forms are gaining much favor over single-unit dosage forms because of their potential benefits like predictable gastric emptying, no risk of dose dumping, flexible release patterns and increased bioavailability with less inter- and intra-subject variability. Based on these premises, the aim of the present review is to survey the main multiparticulate pulsatile delivery systems, for which the swelling and rupturing; dissolution or erosion; and changed permeability of the coating membrane are primarily involved in the control of release. The development of low density floating multiparticulate pulsed-release dosage forms possessing gastric retention capabilities has also been addressed with increasing focus on the upcoming multiparticulate-pulsatile technologies being exploited on an industrial scale. https://biomedpharmajournal.org/vol2no2/chrono-pharmaceutical-drug-delivery-system/ PDDS-Pulsatile drug delivery systems CR-controlled release SR-sustained release