eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-02-15 2 1 141 144 642 article SumaBhaskar 1,2 T. R. S. Chouhan 3 Dr. M. G. R. Educational and Research Institute (Deemed University), Chennai - 600 095 (India). Department of Physiology, Adichunchanagiri Institute of Medical Sciences, B. G. Nagara-571448, Nagamangala Taluk, Mandya District, Karnataka (India). Director, Ethicamatrix CRO Pvt. Ltd, Erragadda, Hyderabad - 500 038 (India) Molecular modeling has become an essential tool in the process of rational drug designing. The interaction between a ligand and its receptor plays a significant role in structure-based drug designing. There is a growing need of improved anticancer agents with more specificity as carcinomas are often unresponsive to or eventually acquire resistance to chemotherapy. In our present study, we have taken a powerful toxic protein molecule, Abrin, as the ligand molecule and docked it with a monoclonal antibody against Carcinoembryonic antigen (CEA) using a computational molecular docking program called Hex 5.1. The results are indicated in terms of energy values with the docked complex achieving an E-value of -658.50. The least energy levels indicate high binding efficiency and steric compatibility. This infers that Abrin can be used as a lead compound since it has a high negative E-value to design a potential anticancer drug which can specifically kill cells over expressing CEA antigens such as in colorectal cancer. These insilico results can thus serve as a template for further studies invitro and invivo. https://biomedpharmajournal.org/vol2no1/docking-studies-of-abrin-with-anti-cea-antibody-its-implications-in-drug-design/ Abrin R. I. P Docking Hex 5.1 Carcinoembryonic antigen Anti-CEA