eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-02-15 2 1 149 152 646 article R. K. Sahu 1 A. Roy 1 A.K. Jha 2 U. Sharma 3 Department of Pharmacognosy, Oriental College of Pharmacy, Bhopal (India). Shri Shankaracharya Institute of Pharmaceutical Sciences, Bhilai, Durg (India). Institute of Pharmacy, Jalpaiguri (India). Kidney, the excretory organ of our body serves the important function of excretion of waste products, regulation of fluid volume and electrolyte content of the extracellular fluid. Diuretics are drugs capable of increasing levels of urine. The diuretic activity of ethanol extract of Pistia stratiotes (ETPS) leaves was studied in male wistar albino rats at 5th h and 24th h intervals. The animals were divided into 5 groups: control, urea, furosemide, 200mg/kg and 400mg/kg ethanol extract. The ethanol extract was administered intraperitoneally (i.p) and all animals were pretreated with saline before starting the experiment. The urine volume (in ml) at 5th h and 24th h duration were measured. The urine output increased significantly in urea, furosemide and both ETPS groups. Ethanol extract increased the urine volume and electrolytes balance in a dose dependent manner. The results indicate that ETPS has significant diuretic activity, which supports the traditional claim about the Pistia stratiotes being used as a diuretic. https://biomedpharmajournal.org/vol2no1/diuretic-activity-of-ethanolic-extract-of-pistia-stratiotes-in-rats/ Pistia stratiotes Diuretics Furosemide Urine volume intraperitoneally