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516Baburao Bhukya¹*, Rama Narsimha Reddy Anreddy² and Krishna Mohan Gottumukkala¹
¹Department of Pharmacognosy and Ethnopharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009 India.
²Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009 India.
Corresponding Author E-mail: babupharma79@gmail.com
Abstract
In present work, the methanolic extract of leaves of Hiptage benghalensis (MEHB) was screened for the analgesic (using hot plate test and acetic acid-induced writhing test in mice) and anti-inflammatory (using rat paw edema test) activity at the doses of 200 and 400 mg/kg body weight. A significant (p<0.0005) analgesic effect was observed with 200 mg/kg and 400 mg/kg in both tests. The maximum anti-inflammatory response was produced at 3 hr and 2 hr with MEHB doses of 200 and 400 mg/kg of respectively. These results suggest that the methanolic extract of Hiptage benghalensis has exhibited significant analgesic and anti-inflammatory effects, which were comparable with standard drugs.
Keywords
Hiptage benghalensis; analgesic; anti-inflammatory; writings; Carrageenan
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| Copy the following to cite this article: Bhukya B, Anreddy R. N. R, Gottumukkala K. M. Analgesic and Anti-Inflammatory Activities of Leaf Extract of Hiptage Benghalensis (L.) Kurz. Biomed. Pharmacol. J.2009;2(1) |
| Copy the following to cite this URL: Bhukya B, Anreddy R. N. R, Gottumukkala K. M. Analgesic and Anti-Inflammatory Activities of Leaf Extract of Hiptage Benghalensis (L.) Kurz. Biomed. Pharmacol. J.2009;2(1). Available from: http://biomedpharmajournal.org/?p=669 |
Introduction
Hiptage benghalensis (L.) Kurz (synonym: Banisteria benghalensis and Hiptage madablota Gaertn) is a herb of the family Malpighiaceae. It is distributed throughout India, Srilanka and the Andaman Islands, Bangladesh and Myanmar to southern China (1). The plant is large, evergreen, climbing shrub with brownish bark peeling off in flakes; young parts silky. Leaves opposite, coriaceolate to elliptic-oblong, apex acute to acuminate, base rounded to cuneate and the margins are entire. In central India, flowering occurs mainly between February and April, sometimes also in October; fruiting occurs mainly from April to June. In ayurveda the leaves and bark are considered vulnerary; the leaves are highly regarded for treating skin diseases. The leaf juice possesses insecticidal properties and is used an external application for scabies. The plant is also used in the treatment of chronic rheumatism and asthma (1). This study has been undertaken to evaluate the analgesic and anti inflammatory activity of the methanolic extract of Hiptage benghalensis using hot plate and rat paw edema method.
Materials and Methods
Plant Material
The leaves of H. benghalensis were collected from Thirupathi hills, Andhra Pradesh, India. It was authenticated by Prof. V. Raju, Dept of Botany, Kakatiya University, Warangal, India.
Preparation of extract
The leaves were cut into small pieces and shed dry and then ground into coarse powder for the maceration process with methanol at room temperature. After exhaustive extraction, the methanolic extract was concentrated under reduced pressure at 50-55 %3
