eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-22 1 2 257 264 2429 article Synthesis of penicillin derivatives and study of their biological antibacterial activities Lakhdar Sekhri 1 Mohammed Lazhar Kadri 1 Choula Samira 1 Moussa Senigra 1 Department of Chemistry, Faculty of Sciences, University of Kasdi Merbah, Ouargla The novel penicillin derivatives Amp-1 and Amx-1 have been synthesised via diazotising aniline with sodium nitrite in a medium of hydrochloric acid and the resulting phenyldiazonium chloride couples to ampicillin and amoxicillin. Esterification of ampicillin and amoxicillin with ethanol and isopropanol yielded the penicillin derivatives Amp-2, Amp-3, Amx-2, and Amx-3. The penicillin derivative Oxa-1 was successfully synthesized by nitration of oxacillin. These penicillin derivatives (except Oxa-1) showed significant activity against all the bacteria tested, Escherichia Coli, Streptococcus pneumonia, Protius, Staphylococcus aureus and Pseudomonas. https://biomedpharmajournal.org/vol1no2/synthesis-of-penicillin-derivatives-and-study-of-their-biological-antibacterial-activities/ Penicilin derivatives Amp-1 Amx-1 Antibacterial activity