eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-22 1 2 425 428 489 article Ch. Narasimharaju BH 1 G. DevalaRao 2 RajendranRukmani 3 A.S.N.Pharmacy College, Burripalem Road, Tenali - 522 201 (Inda). KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada - 520 010 (India). Jaya College of Pharmacy, Thiruninravur - 602 024 (India). This paper describes about validated Reverse phase High Performance Liquid Chromatographic method for determination of Ezetimibe in bulk and pharmaceutical formulations has been developed. Chromatographic separation was carried out using a mobile phase of Potassium dihydrogen phosphate buffer (containing triethylamine) and acetonitrile (55:45v/v) on a C18 –ODS –Hypersil (5 µ, 250×4.6 mm) column in isocratic mode at a flow rate of 1.5ml/minute with UV detection at 234nm. Atorvastatin calcium was used as internal standard. The chromatographic method was linear over the concentration range of 50-250ìg/ml. The Limit of Detection and Limit of Quantitation were 0.828 and 2.5 µg/ml respectively. The mean percentage purity and recovery were found to be 101.22% and 100.36% respectively. Suitable method was developed to determine Ezetimibe in bulk and pharmaceutical formulations. https://biomedpharmajournal.org/vol1no2/reverse-phase-high-performance-liquid-chromatographic-determination-of-ezetimibe-in-bulk-and-pharmaceutical-formulations/ RP -HPLC Ezetimibe Tablets