eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-22 1 2 441 444 503 article Ashish Manigaunha 1 C. S. Senthil Kumar 2 N. Ganesh 2 M. D. Kharya 3 NRI Institute of Pharmacy, Sajjan Singh Nagar, Raisen Road, Bhopal (India). Department of Research, Jawaharlal Nehru Cancer Hospital and Research Center, Bhopal (India). Department of Pharmaceutical Sciences, Dr. H S Gaur University Sagar (India). The present study was aimed to evaluate the hepatoprotective activity of methanolic extract of leaves of Ficus carica Linn. Liver slice culture model have been used to demonstrate hepatoprotective activity of Ficus carica leaves extract in vitro. CCl4 (20mM) has been used as a hepatotoxin and the cytotoxicity of CCl4 is estimated by quantization the release of LDH in the medium. CCl4 induces twice the amount release of LDH from the liver as compared to the cells from untreated liver tissue and this was significantly reduced in presence of Plant extract (10ìg/ml). The results clearly point out that Ficus carica leaves extract mitigates the CCl4 induced liver damage by decreasing LDH level. https://biomedpharmajournal.org/vol1no2/protection-of-hepatic-cells-from-ccl4-induced-cytotoxicity-by-ficus-carica-in-liver-slices-culture-in-vitro/ Hepatoprotective Ficus carica Cytotoxicity Liver slices culture