eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-22 1 2 349 358 452 article M. Rama Rao 1 S. V. Raja Gopal 2 I. Bhaskar Reddy 2 A. D. Naveen Kumar 2 A. Ramesh 2 T. Kartika 2 Department of Biochemistry,College of Science, GITAM Univeristy, Visakhapatnam. Department of Biotechnology, College of Science, GITAM Univeristy, Visakhapatnam (India). Department of Biotechnology, College of Science, GITAM Univeristy, Visakhapatnam (India). Holoptelea intigrifolia is traditionally used for the treatment of inflammatory disease, hemorrhoids. The role of free radicals has been proved in several diseases of inflammatory origin. To understand the pharmacological actions in inflammatory diseases, different types of radical scavenging and 51-lipoxygenase inhibitory activities of methanol extract of bark of H. intigrifolia have been investigated. Methanol extract exhibited significant radical scavenging activities with IC50 values of 105, 115, 265 and 105 mg/ml against 2, 2-diphenyl-1-picrylhydrazyl, super oxide, hydroxyl and nitric oxide radicals respectively. It also showed considerable inhibitory activity against 51-lipoxygenase with IC50 of 55.05 mg/ml. These results can contribute to understand the mechanism involved in the anti-inflammatory effects of the bark extract. https://biomedpharmajournal.org/vol1no2/effect-of-holoptelea-intigrifolia-bark-extract-on-radical-scavening-and-5-lipoxygease-activities/ Inflammatory disease hemorrhoids nitric oxide radical super oxide radical