eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-22 1 2 293 296 427 article Malek Taher Maghsoodlou 1 Noroullah Hazeri 1 Sayyed Mostafa Habibi Khorassani 1 Forough Jalili Milani 1 Mohammad Amin Kazemian 1 Mahdi Shahraki 1 Department of Chemistry, The University of Sistan and Balouchestan, Zahedan (Iran) The reaction between dimethyl acetylenedicarboxylate and biological active heterocyclic NH compounds such as 3-methylpyrazole and 3,6-diboromocarbazole in the presence of triphenylphosphite at room temperature led to phosphonate ester 4a-b. The configuration of compounds 4a-b (2S*,3R*)-were determined on the basis of coupling constants emerged from the Karplus equation. https://biomedpharmajournal.org/vol1no2/diastereoselective-synthesis-of-phosphonate-ester-through-the-reaction-between-activated-acetylenic-ester-and-heterocyclic-nh-compounds-with-biological-activity-in-the-presence-of-triphenylphosphite/ Diastereo selectivity Heterocyclic NH compounds biological activity Activated acetylenic ester