eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-22 1 2 301 304 431 article Nwobodo 1 P. O. Okonkwo 2 Department of Pharmacology and Therapeutics, College of Medicine, Enugu State University of Science and Technology Enugu (Nigeria). Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, (Nigeria). Malaria is a major killer disease affecting one third of the world’s population with untold morbidity and mortality especially in under five children in Sub-Saharan Africa. In a randomized controlled trial, involving 180 children aged 6 to 59 months, (M:F, 1:1.37) with clinically characterized malaria; the efficacy of Amodiaquine (AQ) and Sulfadoxine-Pyrimethamine (SP) as monotherapy and in combination as AQ + SP was evaluated. Results revealed that Fever Clearance Time (FCT) of 28.3±2.3 hours in AQ + SP was significantly different (P<0.05) from 51.2±2.3 hours and 74.6±2.5 hours in AQ and SP respectively. Similarly, the Parasite Clearance Time (PCT) in AQ + SP combination differed significantly (P<0.05) from AQ and SP respectively. There was no reported treatment failure in AQ + SP with a Radical Cure Rate (RCR) of 100%. This contrasts with RCR of 83.5±0.34% and 73.8±0.42% reported for AQ and SP respectively in this study. There was no statistically significant difference P>0.05 in the haematocrit and axillary temperatures at pre and post-treatment in the various treatment groups. In conclusion, the AQ+SP combination is strongly recommended for treatment of uncomplicated P.falciparum malaria especially in under 5 children in Enugu, Nigeria. https://biomedpharmajournal.org/vol1no2/comparative-study-on-the-efficacy-of-sulfadoxine-pyrimethamine-amodiaquine-and-amodiaquine-sulfadoxine-pyrimethamine-combination-in-the-treatment-of-acute-uncomplicated-malaria-in-enugu-state-nig/ Combination therapy efficacy monotherapy malaria