eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-20 1 1 51 60 204 article Malek Taher Maghsoodlou 1 Reza Heydari 1 Norollah Hazer 1 Sayyed Mostafa Habibi-Khorassani 1 Mahmoud Nassiri 1 Mohammad Amin Kazemian 1 Department of Chemistry, The University of Sistan and Balouchestan. Triphenylphosphine reacts with dialkyl acetylenedicarboxylates in the presence of biological active NH heterocyclic compounds, such as (2H) -3-pyridazinone, 1-phenyl-3-pyrazolid- inone, 2,4-thiazolinedione, Rhodanine, 4,5,6,7-tetrahydroindazole and 3-methyl- pyrazole to generate stable phosphorus ylides. These compounds exist in solution as a mixture of two geometrical isomers as a result of restricted rotation around the carbon-carbon partical double bond resulting from conjugation of the ylide moiety with the adjacent carbonyl group. https://biomedpharmajournal.org/vol1no1/synthesis-of-heterocyclic-stable-phosphorus-ylides-from-reaction-between-triphenylphosphine-and-activated-acetylenic-esters-in-the-presence-of-biological-active-nh-heterocyclic-compounds/ Activated acetylenic esters NH heterocyclic compounds Triphenyl- phosphine