eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-20 1 1 201 206 324 article Kapil Kumar Goel 1 Asmita Gajbhiye 1 Anu 2 Nidhi M. Goel 3 Faculty of Ayurved and Medical Sciences (Pharmacy), Gurukul Kangri Vishwavidyalaya, Haridwar. Department of Pharmacy, Bharat Institute of Technology, Meerut . Department of Pharmaceutical Sciences, S.G.R.R.I.T.S, Dehradun . Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya Sagar. The present work to investigate the newer antibacterial and antifungal Agents with less side effect and potent activity.In the present work, a series of 2,6-diaryl-3-methyl-4-piperidones were synthesized by Mannich reaction (condensation) of ethyl methyl ketone, benzaldehyde, substituted aromatic aldehydes and ammonium acetate. Thiosemicarbazone derivatives of 2,6-diaryl-3-methyl-4-piperidones were synthesized by reaction of 2,6-diaryl-3-methyl-4-piperidones with thiosemicarbazide. All the title compounds have been screened for their in vitro antibacterial activity against various strains. Some of these title compounds exhibited significant antimicrobial activity (compared with ampicillin) and antifungal activity (compared with terbinafine). The present study reveals that these compounds could be used as a template for the future development through modification or derivatization to design more potent antimicrobial agents. https://biomedpharmajournal.org/vol1no1/synthesis-and-antimicrobial-activity-of-piperidin-4-one-derivatives/ Piperidin-4-one Thiosemicarbazone Antibacterial agents Antifungal agents