eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-20 1 1 219 222 340 article Arshi Naqvi 1 Mohd. Shahnawaaz 1 Arikatla V. Rao 1 Daya S. Seth 1 School of Chemical Sciences, Chemistry Department, St. John’s College, Agra. Nitrogen containing heterocycles are frequently found in privileged pharmacophores. Pyrazolin-5-ones are important nitrogen-containing five-membered heterocyclic compounds and have been found to be associated with a broad spectrum of bioactivities. The present work is directed towards the synthesis of some substituted-3-methyl-2-pyrazolin-5-ones. The synthesis of title compounds was achieved by the reaction of substituted ²-keto ester with substituted thiosemicarbazides and the synthesized compounds were screened for their antibacterial activity. https://biomedpharmajournal.org/vol1no1/synthesis-and-antibacterial-evaluation-of-substituted-3-methyl-2-pyrazolin-5-ones/ Ethyl-2-substituted phenyl hydrazono-oxobutyrate Substituted thiosemicarbazides  Pyrazolin-5-one