eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2015-01-20 1 1 121 126 251 article Ritesh Jain 1 K. Nandakumar 1 Vishal Srivastava 1 Santosh Kumar Vaidya 1 Shailesh Patel 1 Pradeep Kumar 2 Department of Pharmacology, P.E.S College of Pharmacy, Bangalore. Department of Pharmaceutical Analysis, P.E.S. Collage of Pharmacy, Bangalore, (India). Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Karnataka. Anticonvulsant activity of the aqueous extracts of Aquilaria agallocha Roxb. family Thymelaeceae was studied in Swiss albino mice using the Pentylene tetrazole (PTZ) and Maximal electroshock (MES) convulsion.In Pentylene tetrazole (PTZ) induced convulsion model, aqueous extracts of Aquilaria agallocha (AQAA) 300 and 600 mg/kg, p.o doses significantly increased both the onset of clonus and tonic convulsions induced by PTZ. The effect was dose dependent. In Maximal electroshock (MES) induced convulsion model, 300 mg/kg dose of AQAA exhibited significant anti convulsant effect, there is significant decrease in the duration of extensor phase with increase in the latency of clonus convulsion. The 600 mg/kg of AQAA also increased the latency of clonus in both acute and chronic studies and decreased the duration of extensor phase. From the experimental study it can be concluded that aqueous extract of heartwood of Aquilaria agallocha had exhibited significant anticonvulsant activity in mice. https://biomedpharmajournal.org/vol1no1/anticonvulsant-activity-of-aqueous-extract-of-aquilaria-agallocha/ Aquilaria agallocha Convulsion Pentylene tetrazole (PTZ) Maximal electroshock (MES)