eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-07-29 19 3 72901 article Pande Ayu Naya Kasih Permatananda 1 Sri Masyeni 2 Pande Ayu Berliana Dekananda Pandit 3 Department of Pharmacology, Faculty of Medicine and Health Science, UniversitasWarmadewa, Denpasar, Indonesia 2Department of Internal Medicine, Faculty of Medicine and Health Science, Universitas Warmadewa, Denpasar, Indonesia Department of Pulmonology, Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia Lung cancer is the major cause of cancer-related mortality. The family of regulatory proteins known as Forkhead Box (FOX) transcription factors is involved in cell cycle regulation, programmed cell death, epithelium–mesenchymal transition (EMT), and survival-related signaling. Emerging evidence suggests that dysregulation of FOX family members contributes to lung cancer aggressiveness and therapeutic resistance; however, clinical and translational findings remain heterogeneous.This research intends to comprehensively examinerecent evidence regarding the role of FOX transcription factors as independent molecular variables influencing lung cancer progression, metastasis, and chemoresistance.PubMed/MEDLINE, Scopus, and Embase were searched for relevant articles published from January 2019 to January 2025. Eligible publications comprised original clinical or translational studies, including cohort, case-control, randomized trial, and experimental designs, that evaluated FOX transcription factors in lung cancer.Eight eligible studies were included, most of which focused on non-small cell lung cancer (NSCLC) and used translational experimental approaches. FOXM1 was repeatedly linked with enhanced proliferation, advanced disease, metastatic behavior, and poorer survival. At a mechanistic level, FOXM1 was associated with EMT induction and activation of PI3K/AKT and ERK pathways, supporting its role in therapy resistance. Conversely, FOXO1, FOXO3, FOXP2, and FOXF2 were more often associated with tumor-suppressive activity, including promotion of apoptosis, inhibition of invasion, and improved treatment sensitivity.FOX transcription factors appear to be important regulators of lung cancer biology, particularly in relation to disease progression, metastatic capacity, and response to therapy. https://biomedpharmajournal.org/vol19no3/the-role-of-forkhead-box-transcription-factors-in-lung-cancer-progression-metastasis-and-chemoresistance-a-systematic-review/ Forkhead Box FOXM1 FOXO1 FOXP2 Lung cancer Metastasis Chemoresistance