eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-09-30 19 3 2043 2070 10.13005/bpj/3478 73393 article Lingala Syam Sundar 1 Hiren Mewada 2 Thota Apparao 3 Ratna Sunil Buradagunta 4 Department of Mechanical Engineering, Prince Mohammad Bin Fahd University, Al-Khobar 31952, Saudi Arabia. Department of Electrical Engineering, Prince Mohammad Bin Fahd University, Al-Khobar 31952, Saudi Arabia. Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. Additive Manufacturing Research and Innovation Center, Department of Mechanical Engineering, Prince Mohammad Bin Fahd University, Al-Khobar 31952, Saudi Arabia Centre for Sustainable Infrastructure Materials (SIM), Prince Mohammad Bin Fahd University, Al-Khobar 31952, Saudi Arabia. In tissue engineering (TE), bacterial cellulose (BC) has emerged one of biomaterial that is highly adaptable and promising. It is utilized variety of therapeutic applications, like skin, bone, cartilage, and vascular regeneration. Because of its outstanding qualities, such as its high mechanical strength, superb biocompatibility, excellent moisture retention, and intrinsic capacity to stimulate cell adhesion and proliferation, BC is particularly beneficial for wound healing and skin regeneration procedures. Its importance in skin-related applications is highlighted by the fact that these characteristics speed up the process of tissue repair and encourage the development of new tissue. Additionally, BC is excellent option for bone tissue engineering due to the ability to support osteogenic differentiation. This ability, in conjunction that can facilitate regeneration and repair through bone tissue engineering. Recent breakthroughs have placed an emphasis on the development of hybrid scaffolds based on BC in order to improve tissue-specific capabilities such as vascularization and cartilage regeneration. In order to meet the intricate needs of a wide range of tissue engineering applications, these advancements strive to be implemented. On the other hand, there are still obstacles to overcome, notably with regard of BC manufacturing, the cost-effectiveness, durability of scaffolds that are based on BC. The presence of such obstacles continues to restrict its widespread clinical usage. A rigorous analysis of synthesis methods and current advancements in design of BC based scaffolds is presented in this study. The purpose of this review is to provide insights into the potential of these scaffolds to change regenerative medicine. Additionally, it discusses the primary obstacles and constraints that need to be conquered in order to create the necessary conditions. The BC plays vital role in TE, and therapies, thereby helping to bridge the gap between laboratory research and clinical application. https://biomedpharmajournal.org/vol19no3/recent-development-of-bacterial-cellulose-based-scaffolds-for-tissue-engineering-a-comprehensive-review/ Bacterial cellulose Biomaterials Biomedical Injured tissues Tissue engineering