eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-07-17 19 3 72714 article Indrani Barman 1 Sumira Malik 2 Jutishna Bora 2 Trishna Sharma 3 Jyotismita Sarma 3 Swati Priya 2 Faculty of Paramedical Sciences, Assam down town University, Guwahati, India. Program of Biotechnology, Faculty of Science, Assam down Town University, Guwahati, India. Department of Biotechnology, Amity University Jharkhand, Jharkhand, India. School of Agriculture, Dev Bhoomi Uttarakhand University, Uttarakhand, India School of Agriculture, Uttaranchal University, Uttarakhand, India Institute of Bioscience and Technology, Shri Ramswaroop Memorial University, Uttar Pradesh, India Polycystic ovarian syndrome (PCOS) is a typical hormonal imbalance that affects women who are ready to procreate. In polycystic ovarian syndrome, the ovaries may generate an abundance of small fluid-filled cysts yet fail to release eggs regularly. A high amount of the male hormone produced by polycystic ovarian syndrome delays and unbalances the female body's menstrual cycle. Polycystic Ovarian Syndrome usually synchronizes with a variety of dysglycemia conditions, from Impaired Glucose Tolerance (IGT) towards the commencement of Type 2 Diabetes Mellitus (T2DM), and often appears in greater levels than in healthy women. This synchronism of polycystic ovarian syndrome is solely associated with prevalent pathogenic pathways connecting the two distinct phenomena, like Insulin Resistance (IR), genetics, neuroendocrine, lifestyle/environment, and obesity, which are the prime risk factors that aid in the development of Polycystic Ovarian Syndrome (PCOS). This review research seeks to determine if polycystic ovarian syndrome (PCOS) and type 2 Diabetes Mellitus (T2DM) are related. https://biomedpharmajournal.org/vol19no3/polycystic-ovarian-syndrome-and-diabetes-mellitus-a-bidirectional-endocrine-disorder/ Hyperandrogenism Impaired Glucose Tolerance Insulin Resistance Polycystic Ovarian Syndrome Type 2 Diabetes Mellitus