eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-09-30 19 3 2280 2291 10.13005/bpj/3492 73222 article Mariia Shanaida 1 Tetiana Gontova 2 Mariana Chubka 3 Iryna Krut 1 Mariia Svyshch 1 Yurii Shanaida 4 Department of Pharmacognosy and Medical Botany, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine Department of Pharmacognosy and Nutriciology, National University of Pharmacy, Kharkiv, Ukraine Department of Postgraduate Education and Professional Development of Pharmacists, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine Department of Biotechnical Systems, Ternopil Ivan Puluj National Technical University, Ternopil, Ukraine This study aimed to analyze the volatile compound compositions of three cultivars of Salvia spp. (Salvia officinalis 'Maxima', Salvia farinacea ‘Victoria Blue’, and Salvia yangii ‘Blue Steel’) grown in Ukraine, with a focus on their chemotaxonomic features. To the best of our knowledge, the essential oil compositions of the above-mentioned Salvia cultivars are presented herein for the first time. Based on their key gas chromatography-mass spectrometry (GC-MS) characteristics, 49 volatile compounds were identified in the essential oil of Salvia officinalis 'Maxima', 41 in Salvia farinacea ‘Victoria Blue’, and 32 in Salvia yangii ‘Blue Steel’. The essential oils of all three species are represented mainly by monoterpenoids. Among the oxygenated monoterpenoids, 1,8-cineole was the major compound found in the essential oils of Salvia yangii ‘Blue Steel’ (16.34%) and Salvia officinalis 'Maxima' (14.26%). Cis-salvene, an acyclic monoterpene hydrocarbon, was the key component of Salvia farinacea ‘Victoria Blue’ (12.68%) and Salvia yangii ‘Blue Steel’ (11.51%). The monocyclic monoterpene D-limonene was exclusively identified in the essential oil of Salvia farinacea ‘Victoria Blue’ (12.01%). Among the bicyclic monoterpenoids, α-thujone and borneol were prominent constituents in both Salvia farinacea ‘Victoria Blue’ and Salvia officinalis 'Maxima.' Meanwhile, such bicyclic monoterpenoids as α- and β-pinene were found in significant quantities across all three studied cultivars. It was found that the studied taxa exhibit substantial differences in the qualitative composition of their minor components. Based on the ratio of the predominant compounds in the essential oils, the certain chemotypes of the studied taxa were determined. Considering the proven therapeutic properties of the dominant components of essential oils, the studied taxa could serve as valuable sources of phytosubstances for the development of new medicinal herbal products. https://biomedpharmajournal.org/vol19no3/gc-ms-characterization-and-biomedical-prospects-of-essential-oils-from-three-salvia-spp/ Chemotaxonomic peculiarities Essential oil Gas chromatography-mass spectrometry Sage Terpenoids Volatile compounds