eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-09-30 19 3 2787 27982787 10.13005/bpj/3535 73203 article Yasmin Izadi 1 Salma Kamel 1 Fatima Abdul Rehman 1 Noora Sayed Rasul 1 Mahir Jallo 2 May Khalil 3 College of Medicine, Gulf Medical University, Ajman, UAE Internal Medicine Department, Thumbay University Hospital, Gulf Medical University, Ajman, UAE Biomedical Sciences Department, College of Medicine, Gulf Medical University, Ajman, UAE Hypothyroidism is associated with metabolic dysregulation, particularly lipid abnormalities that may contribute to increased cardiovascular risk. A retrospective observational analysis was conducted to evaluate the association between thyroid dysfunction and metabolic parameters among 300 adults with hypothyroidism attending a tertiary healthcare centre in the United Arab Emirates between June 2020 and April 2025. Demographic, anthropometric, and biochemical variables were obtained from electronic medical records and the relationships between thyroid function indices and metabolic parameters were assessed using correlation and multivariable regression analyses. The mean age of participants was 44.9 ± 11.9 years, and the majority were female and overweight or obese. Hypercholesterolemia and elevated low-density lipoprotein cholesterol (LDL-C) were identified in 37.8% and 28.3% of patients, respectively. Patients with overt hypothyroidism exhibited significantly higher body mass index, total cholesterol, and LDL-C levels than those with subclinical hypothyroidism, although these subgroup findings should be interpreted cautiously given the small number of patients with overt hypothyroidism (n = 9). Serum thyroid-stimulating hormone (TSH) concentrations demonstrated significant positive correlations with total cholesterol, LDL-C, and very-low-density lipoprotein cholesterol (VLDL-C). In multivariable regression models, TSH remained independently associated with total cholesterol (β = 0.485, p < 0.001) and LDL-C (β = 0.417, p < 0.001), and higher TSH levels were independently associated with increased odds of hypercholesterolemia and elevated LDL-C. These findings indicate that thyroid dysfunction is independently related to atherogenic lipid abnormalities in adults with hypothyroidism, highlighting the potential contribution of impaired thyroid function to cardiometabolic risk and the clinical importance of routine lipid monitoring and metabolic risk assessment in this population. https://biomedpharmajournal.org/vol19no3/association-of-thyroid-dysfunction-with-atherogenic-dyslipidaemia-in-adults-with-hypothyroidism-a-retrospective-study/ Cardiometabolic Risk Dyslipidaemia Hypothyroidism Low-Density Lipoprotein Cholesterol (LDL-C) Thyroid Dysfunction Thyroid-Stimulating Hormone (TSH)