eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-06-01 19 2 71964 article Anilkumar Jalindar Shinde 1 Sukeshani Ankush Borde 1 Dinanath Tukaram Gaikwad 1 Firoj Allaudin Tamboli 2 Vijaykumar Tanajirao Pawar 3 Asha Sambhaji Jadhav 4 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur (M.S), India Department of Pharmacognosy, BharatiVidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur (M.S), India Department of Pharmaceutical chemistry, BharatiVidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur (M.S), India Department of Pharmacology, BharatiVidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur (M.S.) India The present study was focused on the formulation and characterisation of nanostructured lipid carrier based topical hydrogel of silymarin for the treatment of psoriasis. NLCs dispersion was characterised for particle size, Polydispersity index, Zeta potential, Entrapment efficiency, morphology, differential scanning calorimetry, and an in vitrorelease study. Optimized NLC incorporated into the hydrogel and characterized for rheological properties, drug content, in-vitro drug release, stability study, skin irritation and antipsoriatic activity by using Perry’s scientific tail model.The optimized NLC batch (B7) was exhibited spherical shape with particle size of 116.9nm, poly dispersity index 0.355, Zeta potential -26.2Mv and entrapment efficiency of 94.63 % respectively. The drug release of optimized batch was 9.23 % and 92.58±0.08% at 1h & 8h respectively. The primary skin irritation index was found to be 0.0757, it indicates barely perceptible irritation. Histopathological studies showed that, in psoriasis-induced animal treated with silymarin loaded NLC hydrogel, marked reduction in thickness of epidermis, as compared to conventional gel formulation. It shows the increase % orthokeratosis 90.28% and % drug activity 58.29 %. Stability studies conducted over 90 days, confirmed that no significant loss in drug content and maintained formulation integrity, which would enhance completeness. The developed NLC based formulation has showed to be a promising carrier system for psoriasis management. https://biomedpharmajournal.org/vol19no2/therapeutic-potential-of-silymarin-loaded-nanostructured-lipid-carrier-hydrogel-in-psoriasis-management/ Herbal Hydrogel Nanostructured Lipid Carriers Psoriasis Silymarin Topical