eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-06-02 19 2 72061 article Noor T.A Alsaadi 1 Marwah T.A Al saadi 2 Mohammad Hailat 3 Sahem Alkharabsheh 4 Wael Abu Dayyih 5 Raed Shudifat 6 Clinical Pharmacy Department, Pharmacy College, Al-Muthanna University, Samawah-Iraq Pharmaceutics Department, Pharmacy College, Al-Muthanna University, Samawah-Iraq Department of Pharmacy,Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Mutah University, Al-Karak-Jordan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak-Jordan 6Department of Adult Nursing, Faculty of Nursing, Mutah University, Al Karak-Jordan Diabetes mellitus is a condition where there is an increase in blood glucose levels due to either decreased insulin synthesis or decreased insulin use. There are other forms of diabetes mellitus, but type 1 and type 2 are the most common. The goal of insulin therapy is to minimize the risk of hypoglycemia while achieving the greatest possible management of blood glucose levels. Insulin administered subcutaneously has some drawbacks, including pain, allergic reactions, hyperinsulinemia, and poor patient compliance. To address these drawbacks, researchers proposed using smart biodegradable polymer-based devices to regulate insulin levels and circumvent the challenges of administering insulin orally, as this review will demonstrate using a variety of techniques. Specifically, this comprehensive review covers smart stimuli-responsive hydrogels based on poly(N-isopropylacrylamide) (PNIPAAm) copolymers for temperature- and pH-dependent oral insulin delivery, poly(lactic-co-glycolic acid) (PLGA) biodegradable microcapsules designed for sustained subcutaneous insulin release with controlled initial burst, biodegradable insulin-loaded nanoparticles prepared via double emulsion and microfluidic/salting-out methods, insulin-albumin microbeads as implantable long-term delivery systems, and glucose-responsive complex polymeric micelles (CPMs) capable of repeated on–off insulin release. https://biomedpharmajournal.org/vol19no2/smart-biodegradable-polymer-based-devices-for-the-regulation-of-insulin-level-a/ Biodegradable polymer Diabetes Drug delivery Hydrogel Insulin Nanoparticles