eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-06-19 19 1 72332 article Mayram Miralievna Boltaeva 1 Zafar Isomiddinovich Sanoev 2 Tolmas Tolibovich Khamroev 12 Ravshan Komiljonovich Sultonov 3 Sirojiddin Rashidovich Kenjaev 4 Nilufar Makhsudovna Dushaeva 5 Department of Rehabilitation, Sports Medicine and Physical Education of Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan Department of Pharmacology and Toxicology of the Institute of Chemistry of Plant Substances named after Academician S.Y. Yunusov of the Academy of Sciences of the Republic of Uzbekistan, Uzbekistan Department of Pharmacology and Toxicology of the Institute of Chemistry of Plant Substances named after Academician S.Y. Yunusov of the Academy of Sciences of the Republic of Uzbekistan, Uzbekistan Department of Morphological Sciences, Termez University of Economics and Service,Termez, Uzbekistan Department of Cardioreanimatology Republican Scientific Center for Emergency Medical Care, Tashkent, Uzbekistan Department of General Medical Sciences, Namangan State University Faculty of Medicine, Namangan, Uzbekistan CVD are the leading cause of death and disability worldwide and arrhythmias, in particular AF, are one of the main causes of death and disability from CVD. In this regard, the main purpose of the work is to conduct preclinical studies on the analysis of promising anti-ventricular fibrillation, as well as anti-atrial fibrillation among known drugs with antiarrhythmic activity, widely used in medical practice. The studies used white mice with a body weight of 18-22 g and white woolless rats with a body weight of 180-250 g. The experiments studied the antiarrhythmic activity of drugs with antiarrhythmic activity of allapinine in doses from 0.05 to 1.5 mg/kg, propafenone from 3 to 10 mg/kg and Amiodarone in doses from 45 to 60 mg/kg administered orally to experimental animals. Rhythm disturbances of peripheral origin were caused by the administration of 15 mg/kg of aconitine and barium chloride, 250 mg/kg of calcium chloride, 0.22 mcg/kg of adrenal hydrochloride and AF by injecting 200 mcg/kg of aconitine into the tail vein of experimental animals. In the conducted studies, allapinine, propafenone and amiodarone also primarily eliminated ventricular rhythm disturbances and then restored the rhythm of the atria. Although the instructions for the use of these drugs in clinical practice also mention ventricular rhythm disorders, in practice we see that these drugs mainly eliminate ventricular rhythm disorders. The quest for methods to broaden the scope of the use of medications that prevent AF is still relevant in medical practice, even though large-scale, important studies of antiarrhythmic pharmaceuticals are now being conducted worldwide. https://biomedpharmajournal.org/vol19no2/preclinical-evaluation-of-antiarrhythmic-drugs-against-atrial-fibrillation-in-experimental-animal-models/ Antiarrhythmic drugs Antiarrhythmic effect Cardiac arrhythmia Electrocardiogram Ventricular extrasystole Ventricular fibrillation