eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-04-17 19 2 71416 article Nitya Kala 1 Ravi Saranyan 1 Dorairaj Jayachandran 1 Mythili Gnanamangai 3 Harikrishnan Prasad 4 Department of Periodontology, Vinayaka Mission’s Sankarachariyar Dental College, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem, Tamil Nadu, India. Department of Periodontics, KSR Institute of Dental Science and Research, The Tamil Nadu Dr. M.G.R. Medical University, Thokkavadi, Tiruchengode, Tamil Nadu, India. Department of Biotechnology, K.S.Rangasamy College of Technology, Anna University, Tiruchengode, Tamil Nadu, India. Department of Oral and Maxillofacial Pathology and Oral Microbiology, KSR Institute of Dental Science and Research, The Tamil Nadu Dr. M.G.R. Medical University, Tiruchengode, Tamil Nadu, India. Porphyromonas gingivalis is an anaerobic Gram-negative coccus known to play a significant role in periodontal disease. Although tetracycline is a potent antibiotic with excellent antibacterial activity against this organism, it should be used judiciously owing to its side effects and the possibility of antibiotic resistance. In the search for alternate treatment strategies against P.gingivalis, herbal products show sufficient promise. Therefore, we performed a scoping review to understand our current knowledge on the efficacy of herbal extracts against P.gingivalis. Using specific keywords, databases like PubMed, Medline, Lilacs, Web of science, and Scopus were searched for in vitro studies reporting the efficacy of various herbal products against Porphyromonas gingivalis. After screening and elimination of irrelevant and duplicate articles, 94 articles were included in this review. Data was extracted from these articles, and the findings are summarised. Numerous herbal extracts have been evaluated for their efficacy against P.gingivalis. Extracts from coffee beans, Moringa oleifera leaves and Allium sativum pods were effective at low concentrations. Artemisia herba-alba showed a maximum zone of inhibition against the organism. Our literature search and review suggest that a wide range of herbal extracts have been evaluated for their effectiveness against P.gingivalis. However, a majority of such extracts have never been evaluated in more than one study, and some do not have proper positive and negative controls, prompting us to view their results with extreme caution. Further research in the form of animal studies and clinical trials is essential to identify and develop a potent alternative to tetracycline for use in periodontal disease management. https://biomedpharmajournal.org/vol19no2/plant-based-antibacterial-strategies-against-porphyromonas-gingivalis-a-systematic-review/ Antibacterial activity Herbal extract Inhibition zone diameter Minimum inhibitory concentration Porphyromonas gingivalis