eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-06-10 19 2 72256 article Vuong Thi Huyen Trang 1 Than Thi Kieu My 2 Nguyen Ly Tra My 3 Hoang Ha My 4 Nguyen Ha Linh 5 Vietnam Academy of Science and Technology, Vietnam Faculty of Medicinal Materials - Traditional Pharmacy, Hanoi University of Pharmacy, Vietnam Renaissance International School Saigon, Vietnam FPT Highschool, Vietnam Foreign Language Specialised School, Ha Noi, Vietnam Vietnam is home to six documented Gynostemma species that have long been used for their health-promoting effects. In recent years, experimental and pharmacological studies have increasingly documented their potential relevance to metabolic disorders. Nonetheless, data on their phytochemical composition and pharmacological activities related to metabolic disorders remain fragmented and have not been thoroughly integrated. This scoping review compiles existing data on the phytochemical constituents, metabolic mechanisms, and safety of Vietnamese Gynostemma species, emphasizing their lipid-lowering, antidiabetic, and hepatoprotective effects pertinent to herbal drug development. The review followed PRISMA-ScR guidelines. Only studies reporting phytochemical or biological evidence on Vietnamese Gynostemma species were included. A total of 56 compounds were reported, including 39 dammarane-type saponins identified in G. pentaphyllum, G. compressum, G. guangxiense, G. burmanicum, G. laxum, and G. longipes. The reported metabolic effects were primarily linked to AMPK activation, inhibition of sterol regulatory element-binding protein-1c (SREBP-1c), and enhanced insulin sensitivity. Limited clinical observations support the lipid-lowering and antidiabetic effects, while existing toxicological data suggest a substantial safety margin, with LD₅₀ values typically exceeding 50-100 g/kg. Taken together, Vietnamese Gynostemma species exhibit consistent phytochemical and pharmacological properties that support their traditional use in metabolic disorders. However, greater standardization of herbal materials and well-designed clinical studies remain essential to translate these findings into evidence-based clinical applications. https://biomedpharmajournal.org/vol19no2/phytochemical-diversity-and-pharmacological-activities-of-vietnamese-gynostemma-species-in-metabolic-disorders-a-scoping-review/ Antidiabetic activity Anti-obesity activity Gynostemma Gynostemma pentaphyllum Hepatoprotective activity Metabolic disorders Phytochemistry Vietnamese medicinal plants