eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-05-13 19 2 71812 article Ahmed Atia 1 Department of Anesthesia and Intensive Care, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya This study provides the first prospective, multi-specialty evaluation of postoperative analgesic prescribing patterns in Tripoli, Libya, systematically linking drug utilization with pain outcomes.A prospective observational study was conducted with 67 adult patients undergoing various surgical procedures. Data collection included analgesic agents, administration routes, therapy modalities, and pain scores using the Numeric Rating Scale recorded twice daily over four postoperative days. Statistical analyses employed chi-square tests, ANOVA, and t-tests to evaluate significant associations. Paracetamol emerged as the predominant analgesic (56.7%, p<0.001), followed by tramadol (26.9%) and fentanyl (14.9%). Intravenous administration was significantly preferred (77.6%, p<0.001), and combination therapy predominated over monotherapy (67.2% vs 32.8%, p<0.001). Novel findings include superior pain reduction in female patients, those receiving spinal anesthesia, and patients undergoing orthopedic or obstetric procedures. These results highlight the effectiveness of paracetamol-based multimodal IV therapy in resource-limited settings and provide evidence for standardizing analgesic protocols in Libyan hospitals.Findings support standardization of multimodal analgesia protocols in Libyan hospitals https://biomedpharmajournal.org/vol19no2/patterns-of-analgesic-prescription-and-pain-control-in-surgical-patients-observations-from-alkhadra-hospital/ Analgesic Patterns Libya Pain Management Postoperative Pain Surgery