eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-05-22 19 2 71979 article Mohammad Shane Alam 1 Yahia Ali Kaabi 1 Fakhra Jabeen 2 Mohammad Mazharul Hoque 3 Alaa Alhazmi 1 Mohammad Suhail Akhter 1 Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia Department of Physical sciences, College of Science, Jazan University, Jazan, Saudi Arabia Department of Emergency Medicine, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia Department of Computer Science, Chrıst University, Delhi NCR, Ghaziabad, India Department of Information Technology, Marwadi University, Rajkot, Gujarat, India This study discusses the effect of diabetes mellitus (DM) and the importance of biochemical markers in the timely diagnosis, management and prognostication of acute myocardial infarction (AMI) through the measurement of cardiac enzymes in diabetic and non-diabetic patients with AMI.A cohort of 300 individuals of ages of 55-80 years were selected for case control study.  Three groups of participants were identified: normal (N), Diabetic Acute Myocardial Infarction (D-AMI), and Non-diabetic Acute Myocardial Infarction (ND-AMI).Each participant underwent a thorough history, medical evaluation, and assessment of cardiovascular parameters.These parameters included fasting blood glucose, glycated hemoglobin (HbA1c), systolic and diastolic blood pressure, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and the ratios of TC/HDL and LDL/HDL.The cardiac biomarkers measured included aspartate aminotransferase (AST), lactate dehydrogenase (LDH), C-reactive protein (CRP), creatine phosphokinase (CPK), creatine kinase-MB (CK-MB), and troponin-I.While TC, TG, and LDL-C levels were high, HDL-C levels were considerably lower in the D-AMI group than in the N-AMI group. Irrespective of whether they had diabetes mellitus, the study's findings demonstrated that individuals with myocardial infarction had considerably higher rates of cardiac biomarkers, including troponin I, CPK, CK-MB, AST, LDH, and CRP.Research indicates that individuals with D-AMI have higher cardiac indicators than those with ND-AMI. https://biomedpharmajournal.org/vol19no2/comparative-evaluation-of-cardiovascular-biomarkers-in-diabetic-and-non-diabetic-myocardial-infarction-patients-in-saudi-arabia/ Acute Myocardial Cardiac Biomarkers Diabetes Mellitus Dyslipidemia Infarction Inflammatory Markers