eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-06-29 19 2 72397 article Biplob kanti Biswas 1 Sadia Jannat Tauhida 1 Md. Mohaimenul Islam Tareq 1 Florence Bornali Ratno 1 Mohammad Ashik Sheikh 1 Md Ridoy Hossain 1 Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore, Bangladesh Department of Pharmacy, Jashore University of Science and Technology, Jashore, Bangladesh. Urinary tract infections are one of the most common bacterial infections in the world and recurrent UTI (rUTI) is a major clinical problem. Genetic polymorphisms in the CXCL8 and its receptor, CXCR1, could affect host susceptibility due to their role in recruitment of neutrophils and clearance of bacteria in the urinary tract. The CXCR1 rs2234671 is a Serine-to-Threonine substitution in the IL-8 receptor A protein, associated with several inflammation-related diseases; however, there is limited data available for South Asian populations. The aim of the present study was to explore the possible relationship between the CXCR1 rs2234671 polymorphism and the risk of recurrent UTI in the Bangladeshi population. A case-control study was performed with 109 patients, including 64 patients with rUTI and 45 healthy controls, who were selected from a tertiary care centre at Jashore, Bangladesh. Peripheral blood was used to isolate genomic DNA, and the CXCR1 region (including rs2234671) was amplified by Polymerase Chain Reaction to generate a 205 bp PCR product. A total of 58 participants (34 cases and 24 controls) were genotyped by Sanger sequencing, and data were compared statistically using the chi-square test. All 34 cases had the homozygous GG genotype, and all 24 controls had the heterozygous GC genotype with no CC genotype being observed. There were significant differences in genotype and in allele frequencies between the groups (p < 0.001) and the C allele was inversely correlated with rUTI susceptibility, but deviations from Hardy–Weinberg equilibrium were seen in the controls. These preliminary findings suggest that the CXCR1 rs2234671 polymorphism may be a candidate genetic marker associated with rUTI susceptibility in this population. However, validation in larger independent cohorts and functional studies is required. https://biomedpharmajournal.org/vol19no2/association-of-the-rs2234671-polymorphism-with-recurrent-urinary-tract-infection-susceptibility-in-the-bangladeshi-population/ Bangladeshi Population CXCR1 rs2234671 Recurrent Urinary Tract Infection Single Nucleotide Polymorphism