eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-05-08 19 2 71707 article Haritha Potluri 1 Lakshmana Rao Atmakuri 2 Usha Rani Nannapaneni 3 Chakrapani Challari 1 Abdul Mathin Shaik 1 Venkata Hari Prasad Potluri 4 Department of Chemistry, Seshadri Rao Gudlavalleru Engineering College, Gudlavalleru, Andhra Pradesh, India. Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, India. Department of FED, PVP Siddhartha Institute of Technology, Vijayawada, Andhra Pradesh, India. Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India. Ipomoea marginata (Desr.) Verdcourt is traditionally used in hypertension, diabetes and fever therapies. This research aims to determine the potential antipyretic function of Ipomoea marginata methonolic crude extract (MEIM) and its fractions in order to facilitate its usage as folk medicine, and to detect the phytochemical components responsible for it by in vivo & in silico studies. MEIM & its fractions were subsequently examined through GC–MS analysis.  In vivo experiments were performed in Wistar albino mice by yeast-induced pyrexia test. In vivo antipyretic experiments demonstrated a substantial decrease of the rectal temperature of about 0.5^°C in all doses for yeast-induced rat pyrexia. The molecular docking of certain significant compounds in MEIM to Cyclo-oxygenase-1, Cyclo-oxygenase-2 & Microsomal-Prostaglandin E Synthase-1 demonstrated noteworthy associations of these target proteins with the retained amino acid residue. Tamarixetin is the compound which attained best docking score. These findings suggest that Tamarixetin, isolated from Ipomoea marginata has a potential therapeutic efficacy for treating fever. https://biomedpharmajournal.org/vol19no2/antipyretic-potential-of-tamarixetin-from-ipomoea-marginata-desr-verdcourt-and-its-validation-by-computational-studies/ ADMET Antipyretic In silico Ipomoea marginata Isolation