eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-06-10 19 2 72122 article Heba Fawzy Gomaa 1 Ruyuf Mohammed AL-Foraih 1 Department of Biology, College of Science, Qassim University, Buraydah, Al-Qassim, Saudi Arabia. As of 2022, obesity was identified as a complex, long-term disorder characterized by excess body fataffects more than 890 million people globally. It significantly increases the risk of diseases, including heart disease, type 2 diabetes, and many cancers, and is brought on by a confluence of lifestyle, environmental, and genetic variables.The goal of the current study is to compare the anti-obesity efficiency of papaya aqueous extract (PAE) with that of orlistat in male rats fed a High-fat diet (HFD). Forty male rats were used in this study; ten of them fed normal diet as the control group (GI), and the remaining thirty rats were fed a HFD for twelve consecutive weeks. The obese rats were divided into three groups at random as follows: GII; ten obese rats were received HFD; GIII: 10 obese rats given an oral intubation dose of 50 mg/kg/day of orlistat(ORL) for 45 days; GIV: PAE (600 mg/kg b.wt.) was given to ten obese rats for forty-five days.Serum oxidative stress marker malondialdehyde (MDA),pro-inflammatory cytokine, interleukin-1β(IL1-β), andobesity markers such as serum insulin, Leptin, resistin, and irisin were estimated by ELISA.  PAE has a notable effect in decreasing their body weight that was clear by a drop in BMI,a decrease inobesity markers such as resistin, leptin, and insulin levels and a decline in the levels of MDA & IL1-β reflecting the anti-obesity & antioxidant capacity of PAE. https://biomedpharmajournal.org/vol19no2/anti-obesity-efficiency-of-papaya-extract-on-high-fat-diet-induced-obese-malealbino-rats/ CaricaPapaya L aqueous extract Catechin High-fat diet Gallic acid Lipid peroxidation and Obesity