eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-03-20 19 1 683 693 10.13005/bpj/3385 71030 article Madyha Hassan Mahmoud 1 Kamal Upreti 2 Mohammed Abdullah Jeraiby 3 Rituraj Jain 4 Yahia Mjery 1 Mahdi Mohammed Alnajai 5 Department of Medical Laboratory Technology, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia Department of Computer Science, Christ University, Delhi NCR Campus, Ghaziabad, India Department of Basic Medical Science, College of Medicine, Jazan University, Jazan, Saudi Arabia Department of Information Technology, Marwadi University, Rajkot, Gujarat, India Laboratory Department, Jazan University Hospital, Jazan University, Jazan, Saudi Arabia Helicobacter pylori (H. pylori) is a common gastric pathogen that is linked to peptic ulcers, gastric cancer and systemic disorders. There is emerging evidence of an association between infection with H. pylori and chronic kidney disease and non-alcoholic hepatic steatosis, and possible renal and hepatic involvement. This study was conducted to assess the relationship between H. pylori and kidney and liver function changes in Saudi Arabian people. Blood samples were collected from 82 participants divided into two groups, namely H. pylori-infected and non-infected. Biochemical analyses were done to determine kidney (creatinine, urea, sodium and potassium) and liver function (ALT, AST, ALP, total protein and albumin). A total of 82 participants were included in the study, of whom 42 (51.2%) tested positive for Helicobacter pylori infection, while 40 (48.8%) were non-infected and served as the control group. Liver enzyme levels (ALP (64.00), AST (21.40), ALT (21.26) and GGT (20.78)) were normal and did not differ significantly between groups (p > 0.05). Regression analysis showed a significant relationship between H. pylori infection and high creatinine (OR = 6.38, p = 0.018). Borderline correlations were found for GGT (OR = 1.179, p = 0.092), uric acid (OR = 2.661, p = 0.061), and the electrolytes and lipid profiles showed no significant variation. H. pylori infection was significantly related to elevated creatinine levels, and may be affecting renal function. Most liver and electrolyte parameters were not affected. Further studies with larger cohorts are required in order to confirm these findings. https://biomedpharmajournal.org/vol19no1/the-impact-of-helicobacter-pylori-infection-on-renal-and-hepatic-function-parameters-in-saudi-arabi-a-case-control-study/ Gastric infection Helicobacter pylori Kidney function test Liver function test Non-alcoholic fatty liver disease