eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-03-20 19 1 545 550 10.13005/bpj/3373 70314 article Elta-Diah Pasmanasari 1 William Tanyawan 1 Dodik-Tugasworo Pramukarso 1 Retnaningsih, Retnaningsih 1 Jimmy-Eko-Budi Hartono 1 Suryadi, Suryadi 1 Department of Neurology, Dr. Kariadi Hospital/Medical Faculty of Universitas Diponegoro, Semarang, Indonesia. Myasthenia Gravis (MG) is an autoimmune disease characterized by muscle weakness due to disorders of the neuromuscular junction. Most patients with Myasthenia gravis have autoantibodies against acetylcholine receptors (AChR). Regulatory T cells (Tregs) are thought to be involved in the pathophysiology of MG, where they influence the maturation and proliferation of B cells (both in the thymus and peripherally). This showed that Tregs play a significant role in the production of autoantibodies in MG disease. The study aims to analyze the correlation among Treg levels, AChR levels, and clinical severity in patients with myasthenia gravis. This is a descriptive analytical study with a cross-sectional design. Outpatients with Myasthenia Gravis in Dr. Kariadi General Hospital in Semarang who met the inclusion and exclusion criteria had their blood drawn and demographic data collected through the electronic medical record. The Treg level was measured by flow cytometry, and the antibody level was measured by ELISA. The correlation between Treg and AChR levels was analysed using the Spearman test, and the association between Treg levels and clinical severity was analysed using the Mann-Whitney test. The research results show a significant, weakly correlated inverse relationship between Treg cell levels and AChR antibodies. (p = 0.049, r = -0.406) and has no significant association with MGFA-PIS score (p = 0,427) https://biomedpharmajournal.org/vol19no1/correlation-between-regulator-t-cell-levels-and-acetylcholine-receptor-antibody-levels-and-clinical-in-patients-with-myasthenia-gravis/ Antibody AChR Autoimmune Disease Myasthenia Gravis Neuromuscular Junction T-regulatory Cell