eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2026-03-20 19 1 767 775 10.13005/bpj/3390 70602 article Mohira Nuraddinova 1 Akmal Islomov 2 Arofat Inkhonova 3 Shukhrat Khakberdiyev 4 Risolat Norboboyeva 5 Akmal Khaitov 6 Department of Medical and Biological Chemistry, Tashkent State Medical University, Tashkent, Uzbekistan Department of Physicochemical Methods of Research, Proteins and Peptides, and Pharmacology, A. S. Sadykov Institute of Bioorganic Chemistry of the Academy of Sciences of Uzbekistan, Uzbekistan. Department of Pharmacy, Alfraganus University, Tashkent, Uzbekistan. Department of Chemical Engineering, Jizzak Polytechnic Institute, Jizzak, Uzbekistan. Department of Biology, Faculty of Natural Sciences, National Pedagogical University of Uzbekistan named after Nizami, Tashkent, Uzbekistan. Head of the Department of Surgical Sciences, Faculty of Medicine, PhD., Termez University of Economics and Service, Termez, Uzbekistan. This article presents methods and results for predicting the pharmacological and biological activity of amyrin substances isolated from the Euphorbia Milii plant using molecular docking and SWISSADME calculations, a quantum-chemical technique. By studying the nature of amyrin substances to determine their binding to proteins through molecular docking, the areas in which these substances can be applied in pharmacological processes have been identified. https://biomedpharmajournal.org/vol19no1/comparative-study-of-the-pharmacological-properties-of-amyrin-compounds-derived-from-the-composition-of-euphorbia-milii-molecular-docking-and-swissadme-calculations/ Amyrin Euphorbia Ligands Molecular docking SWISSADME calculations Receptor