eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-10-27 18 October Spl Edition 68647 article Ranajit Nath 1 Rajesh Ephraim Jesudasan 1 School of Pharmacy, The Assam Kaziranga University, Jorhat, India. Neurological disorders (NDs) remain a major global health burden, and conventional therapies often fail to achieve satisfactory outcomes due to limited brain bioavailability, systemic toxicity, and poor patient compliance. Nanotechnology offers novel opportunities to overcome these challenges, particularly by enhancing drug stability, bioavailability, and targeted delivery across the blood–brain barrier (BBB). A wide range of nanosystems—including lipid-based carriers, polymeric nanoparticles, metallic nanoparticles, and nanomicelles—have been explored for their ability to improve the therapeutic potential of both synthetic and plant-derived compounds. Increasing evidence demonstrates that nanoformulations of phytoconstituents such as curcumin, quercetin, Ginkgo biloba, and Nigella sativa exhibit neuroprotective effects with superior efficacy compared to their free forms. This review critically evaluates the current state of nano-phytomedicine in the management of NDs, highlighting key strengths, limitations, and translational challenges. Special emphasis is given to regulatory hurdles, safety concerns, and the gaps that must be addressed before clinical application. A structured literature search strategy was employed to identify recent advances and ongoing debates in this field. Finally, we propose novel perspectives on how rational design of phytochemical-based nanocarriers, in combination with advanced imaging and molecular tools, could accelerate the development of safe and effective neurotherapeutics. https://biomedpharmajournal.org/vol18octoberspledition/nanoparticles-of-herbal-extracts-in-treatment-of-neurodegenerative-disorders/ Curcumin Herbal extracts Neurodegenerative diseases Nanoparticles   Nanotechnology