eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-12-30 18 4 2680 2688 10.13005/bpj/3285 69367 article Anastasia Yurievna Elkina 1 Irina Vadimovna Kozlova 2 Natalia Sergeevna Akimova 1 Anton Robertovich Kiselev 3 Yuri Grigorievich Schwartz 1 Dept. of Faculty Therapy, Saratov State Medical University, Saratov, Russia Dept. of Therapy, Gastroenterology and Pulmonology, Saratov State Medical University, Saratov, Russia Dept. of Coordinating Center for Fundamental Research, National Medical Research Center for Therapy and Preventive Medicine, Moscow, Russia In the context of advancing precision medicine and  accumulating new data on genetic markers associated with oncological pathologies of a gastroenterological profile, the necessity of evaluating their practical utility becomes particularly significant. The objective of this review is to analyze existing guidelines concerning the primary forms of gastrointestinal cancers from the perspective of the appropriateness of genetic testing, as well as to assess their potential for practical implementation. A comprehensive review of publications in scientific and methodological literature was conducted, focusing on the application of genetic testing for screening hereditary cancer syndromes within gastroenterological practice. The search was performed across SCOPUS, PubMed, Google Scholar, and Russian Science Citation Index databases. For inclusion, meta-analyses, systematic reviews, and original research articles published between 2012 and 2025 were selected. In this review, we present current guidelines regarding genetic testing for the main types of gastrointestinal cancers. The potential applications of genetic analysis in screening for hereditary cancer forms in gastroenterological practice are discussed. The significance of prompt diagnosis of hereditary cancer syndromes is highlighted to enhance patient management and outcomes. Genetic testing plays a crucial role in managing patients with malignant neoplasms of the gastrointestinal tract, irrespective of tumor location or treatment stage. It is important to emphasize that such testing should not be restricted solely to cases of early-onset cancer. The hereditary form of cancer can be suspected by the clinician based on a combination of clinical features, with an understanding that the established thresholds for risk assessment are somewhat conditional and should be interpreted within the broader clinical context. https://biomedpharmajournal.org/vol18no4/the-possibilities-of-using-genetic-testing-in-the-screening-of-hereditary-forms-of-cancer-in-the-practice-of-a-gastroenterologist/ Familial intestinal gastric cancer syndrome Genetic testing Hereditary cancers Genetic oncomarkers Gastric adenocarcinoma Proximal polyposis of the stomach