eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-09-30 18 3 2452 2462 10.13005/bpj/3269 67527 article Essenhaji Sanaa 1 Anaibar Fatima Ezzahra 3 Jarir Jamal 2 Mohammadi Hicham 2 Habbal Rachida 4 Houari Chaymaa 4 Department of Biology; Laboratory of health and environment, Hassan II University, Faculty of Sciences, km 8 Road El Jadida BP5366, Casablanca, Morocco Department of Medical biology; Laboratory of Biochemistry, Pasteur Institute of Morocco, Casablanca, Morocco. Department of Biology; Laboratory of Anthropogenetics, Biotechnology and Health, Chouaïb Doukkali University, El Jadida, Morocco. Department of Cardiology Service, Ibn Rochd University Hospital Center, Casablanca, Morocco. Department of Biology Faculty of Sciences Ben M'Sick ; Sidi Othmane Casablanca, Morocco The prevalence of cardiovascular diseases (CVDs) is steadily rising in Morocco and across North Africa, largely linked to dyslipidemia and persistent inflammatory states. This study was conducted to evaluate lipid profiles alongside High-Sensitivity Troponin I (hs-cTnI) and C-Reactive Protein (CRP) levels. A cohort of 240 healthy individuals served as controls, compared with 351 patients diagnosed with acute CVD. Patients exhibited significantly higher levels of LDL-C (1.48 ± 0.45 g/L vs. 1.14 ± 0.24 g/L), hs-cTnI (10.2 ± 5.3 ng/mL vs. 3.1 ± 1.8 ng/mL), and CRP (9.8 ± 7.9 mg/L vs. 2.4 ± 1.6 mg/L), with all differences reaching statistical significance (p < 0.001). Multivariate logistic regression analysis identified LDL-C, hs-cTnI, and CRP as independent predictors of acute CVD, with odds ratios (OR) of 1.82  (95% CI: 1.45-2.29), 1.06 (95\% CI: 1.03-1.09), and 1.12 (95\% CI: 1.04-1.21), respectively Receiver Operating Characteristic (ROC) curve analysis showed that hs-cTnI had moderate discriminative ability (AUC = 0.70), whereas CRP displayed limited predictive performance (AUC = 0.62). These findings suggest that hs-cTnI, and to a lesser extent CRP, may enhance risk stratification for acute CVD in Moroccan populations, highlighting the need for biomarker-guided protocols that are both effective and resource-conscious in clinical practice. https://biomedpharmajournal.org/vol18no3/high-sensitivity-troponin-i-c-reactive-protein-and-hypercholesterolemia-as-predictors-of-acute-cardiovascular-events-in-morocco/ Cardiovascular Diseases C-Reactive Protein Hypercholesterolemia Morocco North Africa Troponin I.