eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-09-30 18 3 2277 2289 10.13005/bpj/3254 67491 article Aashish Joshi 1 Kailash Karande 2 Ravindra Gunaki 3 Department of Electronics and Telecommunication Engineering, S.K.N Sinhgad College of Engineering, Korti, Pandharpur, Dist Solapur, Maharashtra India Department of Electronics and Telecommunication Engineering, Fabtech Technical Campus College of Engineering and Research, Sangola, Dist Solapur, Maharashtra, India Orthopaedics Department, KVV Krishna Institute of Medical Sciences Deemed University (Krishna Vishwa Vidyapeeth) Karad, Satara, Maharashtra, India This study investigates the application of DHS (Dynamic Hip Screw) stabilization in elderly patients with proximal femur fractures. To ensure clinical fidelity, consultations with orthopedic surgeons were conducted before simulating DHS screw insertion. The primary focus was to analyze the stress distribution patterns in the bone, implant, and interface area under various loading conditions, a critical factor for older patients with stable fractures for whom DHS stabilization is considered optimal. Finite Element Analysis (FEA) was utilized to assess the mechanical behavior of the implant and femur under simulated conditions. The parameters were selected based on the literature available like Von-Misses stress, Concept of Factor of safety. The life cycle parameters like load cycle, allowable range of fatigue and extreme values of the fatigue are also taken care. Since these impact outcome of the simulation. Domain expertise has been received which has helped us deeper understanding and better visualization. To ensure simulation model is adequately calibrated and validated. Subsequently, fatigue analysis for high-cycle loading conditions was conducted, incorporating Factor Of Safety (FoS) computations for both the implant and the post-operative femur bone. The results indicated that the FoS ranged from 1 to 15, with the mid-femur displaying the minimum FoS value of 5, and the proximal femur showing the maximum FoS. This suggests a significant increase in the overall FoS following the virtual operation, demonstrating enhanced stability and structural integrity of the femur post-DHS stabilization. These findings underscore the effectiveness of DHS stabilization in improving load distribution and reducing the risk of further complications in elderly patients with proximal femur fractures. This simulation procedure has been validated with help of expert orthopedic surgeons to perform exact simulations as per the medical practice requirements such validation letters are also obtained as proof for the research work. https://biomedpharmajournal.org/vol18no3/finite-element-analysis-of-proximal-femur-fractures-evaluating-fatigue-performance-and-factor-of-safety-of-dhs-screw-fixation/ Fatigue Analysis Fracture Proximal Femur Bone Stress DHS Screw Factor of Safety (FoS) Finite Element Analysis (FEA) Operative planning Surgical simulation