eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-09-30 18 3 2150 2163 10.13005/bpj/3243 67775 article Abdulkareem Mokif Obais Department of Biomedical Engineering, University of Babylon, Al-Hilla, Babylon, Iraq The electrocardiogram (ECG) signal is vulnerable to various noise interferences during recording, which compromises the precision of subsequent diagnosis. ECG readings, essential for detecting cardiovascular disorders, are highly susceptible to noise, notably power line interference (PLI) at frequencies of 50 or 60 Hz. Severe PLI can obscure or completely conceal specific components, such as P-waves and QRS complexes. The extraction of untainted ECG signals from polluted data is a fundamental difficulty in biomedical signal processing. This paper introduces an adaptive experimental technique for removing the 50Hz power line component from a severely damaged ECG signal by employing iterative 50Hz subtraction circuits and high-order low-pass filters to eliminate various harmonics of 50Hz and other noise sources. The experimental results completely correspond with the design methodology. The resulting ECG signal is suitable for cardiovascular diagnostics. The implemented circuit is low-cost, and all its components are readily available on the market. This device can extract a pristine ECG signal from a noisy environment. https://biomedpharmajournal.org/vol18no3/extracting-an-extremely-corrupted-ecg-signal/ Adaptive filtering ECG spectrum ECG extraction methods Electrocardiographic Power line removal QRS-complex