eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-09-30 18 3 2446 2451 10.13005/bpj/3268 67384 article Ibtihal Ahmed Mohamed 1 Amna Osman M. Elzein 1 Faculty of medical laboratory (clinical chemistry), Alzaeim Alazhari University, Khartoum-Sudan Cystatin c is single non glycated polypeptide chains which is recently   considered as markers in the renal dialysis. Our study aimed to estimate cystatin c and creatinine reduction in Sudanese patients with chronic kidney disease on dialysis. A cohort of forty patients was selected for this study creatinine and cystatin were estimated pre and post dialysis, three ml of blood were drowned by standard methods twice from each patient pre and post dialysis. 20 out of 40 patients with CKD were males while 20 were females, the most patients were more than 50years old 45.5% , 42.5% between 25-50years while 12.5% were less than 25 years. The mean and std of creatinine and cystatin c were reduced significantly in post haemodialysis than pre haemodialysis, the haemodialysis, the reduction ratio were 14.93%(pvalue 0.000) , and 58.50% (p.value0.000) for cystatin C and creatinine respectively.  The pre and post haemodialysis cystatin c were not correlated with haemodialysis duration in years while pre haemodialysis creatinine level were significantly correlated with duration p.value 0.009. In conclusion cystatin C is another sensitive marker beside urea and creatinine reduction ratio further studies were required in different dialysis machine. https://biomedpharmajournal.org/vol18no3/determination-of-cystatin-c-and-creatinine-s-in-sudanese-patients-with-chronic-kidney-disease/ CKD Creatinine Cystatin C Dialysis GFR