eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-09-30 18 3 2305 2314 10.13005/bpj/3257 67016 article Sudhir Patil 1 Kiran Wadkar 3 Department of Pharmacology Bharati Vidyapeeth College of Pharmacy, Palus (M.S.), India Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli. (M.S.), India Department of Pharmacognosy, Dr. Shivajirao College of Pharmacy, Kasbe Digraj, (MS), India. To investigate various facets of breast cancer, a number of animal models have been developed. Chemically induced rodent models, like the MNU model, are suitable for studying malignant progression because rat mammary tumors induced by MNU are predominantly ductal, similar to human breast cancer is strong proof that N-methylnitrosourea (MNU) animal models closely resemble human breast cancer. As a result, it has been extensively utilized to assess his therapeutic and preventative medications for human breast cancer. The progression of malignant tumors can also be studied using chemically produced animal models. Chemopreventive activity of Gliricidia sepium plant extract was studied by MNU induced mammary tumors and animals were evaluated by various parameters like tumor parameter, hematological parameter and histopathological parameters. In current investigation along with chemopreventive effect Serum biochemical parameters, histological results of breast tissue, tumor volume, tumor incidence, tumor burden, and weakly changing body weight have all been measured and it was found that in all parameters  Gliricidia sepium plant extract treated animal shows significant effect. Gliricidia sepium could be one of the effective naturally obtained anticancer remedy for treatment of mammary cancer. The objective for future research is to isolate and characterize each of Gliricidia sepium bioactive components. https://biomedpharmajournal.org/vol18no3/chemopreventive-effect-of-gliricidia-sepium-plant-extracts-in-mnu-induced-mammary-tumor-model/ Antioxidant Breast Tumor Ductal Carcinoma Gliricidia sepium MNU