eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-06-30 18 2 1746 1749 10.13005/bpj/3210 66591 article Mohamed Nabil Ibrahim 1 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Qurayat, KSA The global health crisis triggered by the SARS-CoV-2 pandemic has illuminated the intricate interplay among viral infections, psychological well-being, and digital engagement. This commentary synthesizes clinical insights, public health data, and interdisciplinary frameworks to examine how these domains converge to influence post-viral recovery. Persistent neuropsychiatric symptoms following viral infections, compounded by excessive digital engagement, form a cyclical interaction that exacerbates mental health challenges. Vulnerable populations, including adolescents and older adults, face heightened risks due to unique psychological and behavioral patterns. Addressing this triad requires integrated mental health interventions, digital literacy initiatives, and cross-sector collaborations. Further empirical studies are needed to establish causal pathways and develop targeted interventions for this triadic burden. This holistic perspective is critical for advancing post-pandemic health strategies. https://biomedpharmajournal.org/vol18no2/viral-infections-psychological-stress-and-digital-overuse-a-critical-triad-in-post-pandemic-mental-health/ Digital behavior Digital overuse Mental health Neuropsychiatric sequelae SARS-CoV-2 Viral infections