eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-06-30 18 2 1090 1109 10.13005/bpj/3155 65908 article Binoy Varghese Cheriyan 1 Kaniga Pandi 1 Jubilee Ramasamy 2 Rithikha Sooriyaprakash 1 Sam Jebaraj 1 Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India. Department of Pharmacology, Saveetha College of Pharmacy, SIMATS, Chennai, Tamil Nadu, India. Traditional Chinese medicine has long utilized Hedyotisdiffusa (Bai Hua She She Cao) for its diverse therapeutic properties, including anticancer potential. The study examines its mechanisms of action, bioactive compounds, and synergistic effects with conventional cancer therapies.A literature review analyzed studies on Hedyotisdiffusa, focusing on its anticancer effects, including apoptosis induction, metastasis suppression, angiogenesis inhibition, and modulation of molecular pathways like NF-κB, STAT3, and VEGF.Hedyotisdiffusa demonstrated significant anticancer activity, targeting key pathways and reducing cancer cell proliferation, metastasis, and angiogenesis. Its bioactive compounds, such as polysaccharides and flavonoids, enhanced chemotherapy and radiation therapy efficacy while mitigating side effects.By integrating traditional and modern medicine, Hedyotisdiffusa presents a promising complementary cancer therapy. Its clinical applications require more investigation and optimize its role in oncology. https://biomedpharmajournal.org/vol18no2/phytochemicals-pathways-mechanisms-and-clinical-applications-a-comprehensive-review-on-hedyotis-diffusabai-hua-she-she-cao-in-cancer-management/ Apoptosis induction Bioactive compounds Cancer therapy Hedyotisdiffusa Traditional Chinese Medicine