eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-06-30 18 2 1272 1288 10.13005/bpj/3168 65467 article Kamal Upreti 1 Jossy George 1 Sheela Hundekari 2 Mohammad Shabbir Alam 3 Department of Computer Science, CHRIST (Deemed to be University), Delhi NCR, Ghaziabad, Uttar Pradesh, India Department of Computer Science and Engineering, Pimpri Chinchwad University, Maval Talegaon, Pune, Maharashtra, India Department of Computer Science, College of Computer Science and Information Technology, Jazan University, Jazan, KSA This paper develops an optimized hybrid approach to predict infertility with the HyNetReg Model. The HyNetReg Model combines deep feature extraction by using neural networks with logistic regression with regularization. It uses both hormonal and demographic information of 100 participants to clarify intricate interlinkages between demographic factors and salient hormonal levels, such as Luteinizing Hormone, Follicle Stimulating Hormone, Anti-Müllerian Hormone, and Prolactin, and the ability of these same factors to affect fertility outcomes. It applies heavy data pre-processing including normalization, missing values imputation, and class imbalance handling through oversampling techniques. A multi-layer neural network is utilized to extract features for the reduction of complex, non-linear interaction among the input variables. Then, regularized logistic regression is applied for classification on the same features. Performance evaluation metrics, including accuracy, precision, recall, F1-score, and ROC curve analysis, demonstrate the superiority of the HyNetReg Model over traditional logistic regression. The ROC curve was specifically utilized to assess the model’s discrimination ability between infertile and fertile cases by plotting the true positive rate (sensitivity) against the false positive rate (1-specificity). A higher Area Under the Curve indicated that the model effectively distinguished infertility risks based on hormonal and demographic features. The results indicate that the model can recover very slight interdependencies of hormones and influences of demographics, making it suitable for modeling multi-factorial determinants of infertility and holding significant implications for clinical decision-making. https://biomedpharmajournal.org/vol18no2/optimized-hybrid-prognostics-using-hynetreg-model-for-infertility-prediction/ Luteinizing Hormone (LH) Follicle Stimulating Hormone (FSH) Anti-Müllerian Hormone (AMH) Alpha-Feto-Protein (AFP) Idiopathic Female Infertility (IFI) Blood Urea Nitrogen (BUN) multi-layer perceptron (MLP) poor ovarian response (POR) recurrent reproductive failure (RRF) total motile sperm count (TMSC)