eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-06-30 18 1 1230 1245 10.13005/bpj/3165 65851 article Sandeep Sharma 1 Saruchi 2 Avneesh Narwal 1 Kanaparthi Chandra Meghana 1 Manjeet Singh 1 Rohit Kumar Maurya 1 Department. of Computer Science Engineering, Lovely Professional University, Phagwara Punjab, India Department of Computer Science Engineering Chandigarh University, Gharuan, Mohali, Punjab India Chronic kidney disease is a progressive condition that often remains undiagnosed until its later stages due to the absence of noticeable symptoms. Early detection is essential for timely intervention and treatment. Whereas other research has mostly centered on the detection of kidney disease in later stages, this research contributes to the field by combining predictive modeling in order to ascertain disease progression in earlier phases. Through the use of both multi-classification and binary classification methods, this research improves the knowledge of chronic kidney disease progression, enabling specific treatment approaches. Sophisticated machine learning algorithms like K-Nearest Neighbor, Decision Tree, and Random Forest have been used to evaluate the accuracy of disease stage prediction. Comparative analysis of different predictive models indicates their efficiency, resulting in enhanced diagnostic accuracy and efficiency. This study adds value to the health industry through the application of machine learning in the early diagnosis and improved management of diseases. Disease prediction enables clinicians to apply timely interventions, minimize complications, and in the end, decrease morbidity and mortality rates related to kidney disease. All these activities come in line with the world aim of enhancing health outcomes and well-being. The anticipated predictive model evidenced a precision rate of 99.16 percent, outpacing other studies using different machine learning classifiers such as Random Forest Classifier, Ada Boost Classifier, Cat Boost, Stochastic Gradient Boosting, Gradient Boosting Classifier, Extreme Gradient Boosting, K-Nearest Neighbor, Extra Trees Classifier, and Decision Tree Classifier. This paper strengthens the importance of artificial intelligence in promoting the diagnostics of chronic kidney disease as well as outcomes in patient care. https://biomedpharmajournal.org/vol18no2/machine-learning-algorithm-for-detecting-and-predicting-chronic-kidney-disease/ Chronic Kidney Disease Decision tree K-Nearest Neighbors Machine learning Random forest