eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-06-30 18 2 1152 1163 10.13005/bpj/3159 65689 article Nicolás Padilla-Raygoza 1 Gilberto Flores-Vargas 1 Omar López-Guzmán 1 Yaret Valeria Rodríguez-Aguilar 1 Department of Research and Technological Development, Directorate of Teaching and Research, Institute of Public Health from Guanajuato State, Guanajuato, México Inulin is a prebiotic that helps modulate various functions in the host organism through multiple systemic and local pathways. It modulates the microbiota, promoting the presence of bifidobacteria, also influence on lipid homeostasis. It occurs due to the interaction of its degradation metabolites with diverse metabolic pathways or components, such as the microbiota and intestinal barrier, or by promoting the growth of specific beneficial microorganisms. A notable effect of prebiotics is their influence on inflammation markers, mainly IL-6 and TNF-α, which are elevated in multiple pathologies and negatively impact health; this effect could be by the direct effect of inulin on the decrease in the expression of inflammatory factors such as NF-kB, TNF-a, and IL-6, and depends on the inhibition of the NF-kB pathway. In obesity there is a chronic inflammation with increase of TNF-𝛂 and the    lipopolysaccharides  has a role in developing insulin resistance, diabetes, and obesity; inulin seems to have an effect on both. Also,  due to its effect on inflammation markers, it could also have a beneficial effect in the case of inflammatory bowel disease. It is needed to know the effect of inulin on diabetes and depression among others diseases where inflammation markers are increased. Apparently the benefits of inulin on various diseases are due to its effect on the intestinal microbiota and on inflammation markers. This review focuses on summarizing inulin's effects on inflammation markers and it opens the possibility to research the effects of inulin in the human health against many diseases. https://biomedpharmajournal.org/vol18no2/inulin-and-its-effect-on-inflammation-markers-a-literature-review/ Dysbiosis Inflammation markers IL-6 TNF-alpha Inulin Microbiota