eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-06-30 18 2 1050 1084 10.13005/bpj/3153 66271 article L. Syam Sundar 1 Department of Mechanical Engineering, College of Engineering, Prince Mohammad Bin Fahd University, Al-Khobar, Saudi Arabia The potential of biodegradable materials and their alloys for use in biomedical applications has drawn a lot of attention. The most common biodegradable materials are graphene oxide (GO), iron (Fe), magnesium (Mo), and zinc (Zn), which has led to a great deal of research into the creation of new alloys. These metals are appropriate for bio-implant use due to their excellent mechanical integrity, adequate biocompatibility, and inherent biodegradability. The recent developments in biodegradable implants in the biomedical field in this thorough study, concentrating mostly on orthopedic applications were examined. The mechanical characteristics, corrosion mechanism, and degrading behavior of these materials both in-vitro and in-vivo are thoroughly examined in this work. The surface modification and fabrication methods, which are essential for maximizing implant performance are also explained. However, their extensive use has been hampered by specific constraints related to alloying materials, particularly iron and zinc. Additionally, the potential highlight of novel metals with exceptional qualities, like molybdenum, which could lead to implants with better mechanical qualities. All things considered, this study highlights the growing importance of biodegradable metallic implants and demonstrates how they can be used to meet a variety of clinical objectives. By overcoming material constraints and utilizing cutting-edge metals, the door is opened to create the implants of exceptional mechanical qualities, favourable rates of degrade, transforming the biomedical application space. https://biomedpharmajournal.org/vol18no2/in-vitro-and-in-vivo-responses-of-functional-biodegradable-materials-for-bone-implant-applications-a-comprehensive-review/ Biodegradable Bone regeneration Bone healing Graphene oxide Metal alloys