eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-06-30 18 2 1512 1523 10.13005/bpj/3189 66554 article Driton Sopa 2 Antonino De Lorenzo 1 Laura Di Renzo 1 Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Division of Clinical Nutrition and Nutrigenomics, Rome, Italy Department of Clinical Biochemistry, University Clinical Center of Kosovo, Pristina, Kosovo Individuals with DM2 were the subjects of this study. The nutritional intervention was made according to the IF food regime with a 6-hour feeding window of 24 hours, according to the low-calorie, low-carb diet (IF 6/24-LCD). Three checkpoints were used: phase T0, which was before to the intervention's commencement; phase T1, which was four weeks after the start of the intervention; and phase T2, which was the concluding phase, which was eight weeks after the intervention. The average results of the laboratory tests for TG/HDL ratio 3.23 ±0.36, Homa-IR 6.99±1.37, HbA1c 8.19± 1.21, and glycemia were 9.02± 1.78.In T2, the average weight loss based on BMI was 29.60±3.85 (p > 0.032), or a -9.4 ∆% percentage difference from T0. The average W/H-ratio was 0.98±0.04 to 0.957±0.02 (p > 0.005). The TG/HDL ratio ranged from 3.23±0.36 to 1.20±0.36 on average (p > 0.007).  (P=0.036) HbA1c from 8.19±1.21 to 6.99±1.23. While ketonuria was found in the urine in both control phases T1 and T2, at 1.84± 0.81 mmol/L and 1.75±0.17 mmol/L, respectively, the presence of ketones in the urine was not observed in the T0 phase (0,195±0.07 mmol/L). The study's BMI/ketone correlation was negative, indicating that the nutritional intervention was beneficial based on IF-LCD. This is because the metabolic shift during lipolysis causes fat mass to decrease. It also resulted in a positive correlation between TG/HDL-ratio after nutritional intervention. To our knowledge, this is the first study of its kind conducted in Kosovo, offering novel insights for localized diabetes management strategies. https://biomedpharmajournal.org/vol18no2/impact-of-a-low-carb-diet-on-obese-patients-with-type-2-diabetes-based-on-the-intermittent-fasting-regimen/ DM2 Insulin resistance Intermittent fasting Low carbs diet Metabolic syndrome Obesity