eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-06-30 18 2 1164 1175 10.13005/bpj/3160 66020 article Margret Chandira Rajappa 1 Dominic Antonysamy 2 Karthikeyan Muthumani 1 Vignesh Vezhaventhan 1 Sanjay Gnanamoorthi 5 Ranjithkumar Sivaji 6 Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Yercaud main road, Salem, Tamil Nadu, India. Faculty of Engineering, Sona College of Technology, Salem, Tamil Nadu, India. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome represents a rare yet grave consequence of medication usage, among which mefenamic acid, a widely utilized nonsteroidal anti-inflammatory drug (NSAID), stands as a notable culprit. This review carefully examines the complex relationship between mefenamic acid and DRESS disease, exploring the subtleties of its epidemiology, underlying pathophysiological mechanisms, diverse clinical manifestations, diagnostic challenges, therapeutic modalities, prognostic implications, and preventive strategies. This article aims to strengthen medical community awareness, identification, and effective therapy of mefenamic acid-induced DRESS syndrome by combining current knowledge with emerging research initiatives. https://biomedpharmajournal.org/vol18no2/dress-syndrome-a-comprehensive-review-of-its-clinical-and-systemic-complexities/ DRESS Syndrome Epidemiology Mefenamic Acid NSAID Pathophysiological Mechanisms Preventive Strategies