eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-06-30 18 2 1432 1440 10.13005/bpj/3182 66344 article Khalid Mohammad. Abu-Khadra 1 Mohammad Ahmad Wahsha 2 Tariq Hassan Al-Najjar 3 Department of Biological Sciences, Yarmouk University, Irbid, Jordan Marine Science Station, The University of Jordan, Aqaba Branch, Jordan Department of Marine Biology, The University of Jordan, Aqaba Branch, Jordan Genetic association studies are beginning to play a role in studying and analysing the risk factors of many complicated metabolic disorders, such as Type 2 Diabetes Mellitus (T2DM). This study appraises the association between the SLC30A8 gene polymorphism (rs13266634 C/T) and T2DM in North Jordan as a potential genetic risk factor for T2DM. The rs13266634 polymorphism was analysed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).  The CT genotype was the most prevalent in T2DM (84%) and nondiabetic control groups (91.2%). The TT genotype was observed in only 5.5% of the T2DM group and 4.9% of the nondiabetic group. Allelic analysis disclosed that 49% of the studied population have the T allele, and 51% have the C allele. There were no significant differences in the genotype distribution between the T2DM and the control groups, suggesting that the SLC30A8 gene polymorphism (rs13266634 C/T) is not associated with T2DM in North Jordan and indicating that the SLC30A8 rs13266634 polymorphism is not considered a genetic risk factor for T2DM in the North Jordanian population. https://biomedpharmajournal.org/vol18no2/analysis-of-the-association-between-slc30a8-gene-polymorphism-rs13266634-c-t-and-type-2-diabetes-mellitus-in-the-north-of-jordan/ Gene Polymorphism Genetic Association North Jordan SLC30A8 Type 2 Diabetes Mellitus