eng Oriental Scientific Publishing Company Biomedical and Pharmacology Journal 0974-6242 2025-03-31 18 1 499 515 10.13005/bpj/3103 64093 article Putu Indah Budi Apsari 1 I Ketut Suryana 3 Bagus Komang Satriyasa 4 Dewa Ayu Agus Sri Laksmi 5 Dyah Kanya Wati 6 I Made Agus Gelgel Wirasuta 7 Doctoral Program. Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia Parasitology Department, Faculty of Medicine and Health Sciences, Warmadewa University, Denpasar, Bali, Indonesia Internal Medicine Department, Prof. Ngoerah Hospital, Denpasar, Bali, Indonesia Pharmacology Department, Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia Parasitology Department, Faculty of Medicine Universitas Udayana, Denpasar, Bali, Indonesia Child Health Department, Prof. Ngoerah Hospital Denpasar, Denpasar, Bali, Indonesia Antimalarial resistance remains a problem in malaria elimination programs worldwide. Andrographolide is a labdane diterpenoid extracted form Andrographis paniculata that introduced as a new antimalarial agent, but its potential to prevent resistance must be elaborated to mitigated risk of resistance. This systematic review aimed to analyze the potential of andrographolide to prevent plasmodium resistance. A systematic review was made by comprehensive searching in several database such as PubMed, Google scholar, Science direct with keyword: andrographolide, malaria, plasmodium, resistance, review with several method of study includes in vivo, in vitro, in silico and randomized control trial. We mapped research development of andrographolide to be antimalarial agent using Vos viewer to extract co-occurrence terms that related to andrographolide as antimalarial. Based on PRISMA results, 35 articles meet criteria. Type of andrographolide and its derivative use as treatment, type of study, control, analytical method and result of mechanism of action was compiled within the review table. Andrographolide effective as antimalarial agent, its mechanism includes suppressing parasite numbers, suppressing the inflammatory response in malaria, prevent detoxifying heme, immunomodulating host cells, potent antioxidant, and inhibiting enzymes that play a role in parasite invasion. Further research of andrographolide to prevent antimalarial resistance in Plasmodium must investigated deeply. https://biomedpharmajournal.org/vol18no1/towards-andrographolide-as-antimalarial-a-systematic-review/ Andrographolide Malaria Plasmodium Resistance